perform surgery on; "The doctors operated ont he patient but failed to save his life"
happen; "What is going on in the minds of the people?"
perform a movement in military or naval tactics in order to secure an advantage in attack or defense
handle and cause to function; "do not operate machinery after imbibing alcohol"; "control the lever"
keep engaged; "engaged the gears"
perform as expected when applied; "The washing machine won''t go unless it''s plugged in"; "Does this old car still run well?"; "This old radio doesn''t work anymore"
direct or control; projects, businesses, etc.; "She is running a relief operation in the Sudan"